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NICARDIPINE
SynDRA canonical compound SYN0007800 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
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| Primary target(s) | CACNA1C |
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| Mechanism of action | Calcium channel blocker |
|---|
| Indication | chronic stable angina | hypertension |
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| Disease area | cardiology |
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All known targets
- CACNA1C
- ADORA3
- CACNA1D
- ABCB1
- CYP2C9
- ampC
- Slc29a1
- NR1I2
- MDH1
- Kcna4
- KCND3
- KCND2
Mechanisms of action (all sources)
- Calcium channel blocker
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- ADORA3 ANTAGONIST
- potassium channel blocker
Drug classes
- Calcium Channel Antagonists
- Dihydropyridine Calcium Channel Blocker
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
- Cytochrome P450 2D6 Inhibitors
- Cytochrome P450 2C19 Inhibitors
- Cytochrome P450 3A4 Inhibitors
- Cytochrome P450 2C8 Inhibitors
ATC classes
- C08C · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Cross-references
Synonyms
- (+/-)-Nicardipine
- perpidine
- nicardipine hydrochloride
- nicardipine HCl
- Nicardipino
- Nicardipine (stn)
- Perpidine
- Nicardipinum
- Cardene IV
- Nicardipine LA
- Cardene (TN)
- Nicardipine (INN)
- Nicardipine [INN:BAN]
- Nicardipino [INN-Spanish]
- Nicardipinum [INN-Latin]
- Y-93
- Methyl 2-[methyl(phenylmethyl)amino]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 2-(Benzylmethylamino)ethylmethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(benzylmethylamino)ethyl methyl ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-(benzylmethylamino)ethyl methyl ester
- 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- CZ5312222S
- (+-)-nicardipine
- CHEBI:7550
- DTXCID903363
- nicardipina
- LA, Nicardipine
- RefChem:56587
- Hydrochloride, Nicardipine
- C08CA04
- Cardene
- YC-93 (free base)
- MFCD00216027
- NCGC00015747-03
- NICARDIPINE [INN]
- CAS-55985-32-5
Reported adverse events
- Asthenia
- Constipation
- Dizziness
- Dyspepsia
- Flushing
- Headache
- Insomnia
- Malaise
- Myalgia
- Nausea
- Nervousness
- Nocturia
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