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VISMODEGIB

SynDRA canonical compound SYN0012015 — structure-anchored drug synonym record

All known targets

• SMO
• ABCG2
• ABCB1
• CYP2C19
• CYP2C8
• DHH
• IHH
• PTCH1
• SHH
• Shh

Mechanisms of action (all sources)

• hedgehog pathway inhibitor
• Smoothened receptor antagonist
• SMO inhibitor
• Smoothened homolog inhibitor
• SMO ANTAGONIST
• SMO MODULATOR

Drug classes

• Smoothened Receptor Antagonists
• Hedgehog Pathway Inhibitor

ATC classes

• L01X · OTHER ANTINEOPLASTIC AGENTS

Cross-references

• PubChem CID: 24776445
• ChEMBL: CHEMBL473417
• DrugBank: DB08828
• ChEBI: CHEBI:66903
• KEGG: D09992
• RxNorm: 1242987
• PDB: VIS
• Wikipedia: Vismodegib
• TTD: D03EDQ
• LINCS BRD: BRD-K44827188

Synonyms

• erivedge
• GDC-0449
• RG3616
• NSC-747691
• NSC-755986
• Erivedge
• GDC 0449
• 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide
• Vismodegib (GDC-0449)
• HhAntag691
• GDC0449
• UNII-25X868M3DS
• CHEMBL473417
• CHEBI:66903
• 25X868M3DS
• NSC755986
• AK-77261
• 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide
• C19H14Cl2N2O3S
• 2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide
• 2-chloro-n-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)benzamide
• Erivedge (TN)
• Vismodegib (SHH inhibitor)
• NSC 747691
• 2-chloro-n-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide
• 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
• 2-chloro-N-(4-chloro-3-pyridin-2-yl-phenyl)-4-methanesulfonyl-benzamide
• Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-
• 2-Chloranyl-~{n}-(4-Chloranyl-3-Pyridin-2-Yl-Phenyl)-4-Methylsulfonyl-Benzamide
• GDC-0449 (Vismodegib)
• Vismodegib [USAN]
• Vismodegib [USAN:INN]
• vismodegibum
• HSDB 8130
• R-3616
• NSC747691
• Hh-Antag691
• HhAntag 691

Reported adverse events

• Ageusia
• Alopecia
• Arthralgia
• Constipation
• Dysgeusia
• Fatigue
• Muscle spasms
• Nausea
• Stevens-Johnson syndrome
• Vomiting
• Decreased appetite
• Drug-induced liver injury