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ALISKIREN

SynDRA canonical compound SYN0014414 — structure-anchored drug synonym record

All known targets

• REN
• ABCB1
• CYP3A4
• Ren1
• protease

Mechanisms of action (all sources)

• Renin inhibitor
• protease inhibitor
• Peptidase inhibitor
• Anti-hypertensive agent
• REN INHIBITOR

Drug classes

• Enzyme Inhibitors
• Protease Inhibitors
• Renin Inhibitors
• Renin Inhibitor

ATC classes

• C09X · OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
• ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS

Cross-references

• PubChem CID: 5493444
• ChEMBL: CHEMBL1639
• DrugBank: DB09026
• ChEBI: CHEBI:601027
• KEGG: D03208
• RxNorm: 325646
• PDB: C41
• Wikipedia: Aliskiren
• TTD: D03SVX
• LINCS BRD: BRD-K30020243

Synonyms

• rasilez
• tekturna
• aliskiren hemifumarate
• aliskiren fumarate
• SPP100
• Aliskirene
• Aliskireno
• SPP-100
• Rasilez
• SPP 100
• Rasilez (TN)
• Tekturna (TN)
• Aliskiren (USAN/INN)
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(propan-2-yl)nonanamide
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
• (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide
• Octanamide, .delta.-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-.gamma.-hydroxy-4-methoxy-3-(3-methoxypropoxy)-.alpha.,.zeta.-bis(1-methylethyl)-, [.alpha.S-(alpha.R*,.gamma.R*,.delta.R*,.zeta.R*)]
• aliskirene
• CGP-60536
• CHEBI:601027
• CGP-060536B
• aliskirenum
• RefChem:56248
• C09XA02
• CGP060536B
• DTXCID401030595
• CGP60536
• Aliskiren(CGP 60536)
• MFCD09839018
• CGP60536B
• Aliskiren [INN]
• C30H53N3O6
• NCGC00186464-01
• CGP 60536;CGP60536B;SPP 100
• Aliskiren [USAN:INN:BAN]
• UNII-502FWN4Q32
• Aliskiren?
• HSDB 7843

Reported adverse events

• Angioedema
• Hypersensitivity
• Hypotension
• Erythema
• Cough
• Urticaria
• Severe cutaneous adverse reaction
• Stevens-Johnson syndrome
• Vomiting
• Nausea
• Seizure
• Blood creatinine increased