← SynDRA

DOVITINIB

SynDRA canonical compound SYN0016425 — structure-anchored drug synonym record

All known targets

• FGFR3
• FLT1
• FLT3
• FLT4
• KDR
• KIT
• PDGFRB
• EGFR
• FGFR1
• PDGFRA
• CSF1R
• FGFR2

Mechanisms of action (all sources)

• EGFR INHIBITOR
• FGFR inhibitor
• FLT3 INHIBITOR
• PDGFR inhibitor
• VEGFR inhibitor
• FGFR3 INHIBITOR
• Fibroblast growth factor receptor 3 inhibitor
• Tyrosine-protein kinase receptor FLT3 inhibitor
• KIT INHIBITOR
• Stem cell growth factor receptor inhibitor
• PDGFRB INHIBITOR
• Platelet-derived growth factor receptor inhibitor

Cross-references

• PubChem CID: 135398510
• ChEMBL: CHEMBL522892
• DrugBank: DB05928
• ChEBI: 91395
• KEGG: D08907
• PDB: 38O
• TTD: D07OZR
• LINCS BRD: BRD-K85402309

Synonyms

• TKI-258
• CHIR-258
• GFKI-258
• NVP-TKI258
• TKI258
• Chir 258
• TKI 258
• 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
• CHIR258
• Dovitinib (TKI-258, CHIR-258)
• UNII-I35H55G906
• CHEMBL522892
• I35H55G906
• (3Z)-4-Amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]-2(3H)-quinolinone
• C21H21FN6O
• 4-Amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one
• Dovitinib [INN]
• Dovitinib lactate
• CHEMBL4578973
• 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one
• 4-Amino-5-Fluoro-3-(6-(4-Methylpiperazin-1-yl)-1H-Benzo[D]Imidazol-2-yl)Quinolin-2(1H)-One
• 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one
• (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one
• 4-AMINO-5-FLUORO-3-[ 5- (4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE
• Dovitinib, Free Base
• 38O
• MFCD10565680
• TK-258
• Kinome_1513
• Dovitinib (TKI-258)
• DOVITINIB [WHO-DD]
• MLS006009991
• SCHEMBL172687
• GTPL5962
• SCHEMBL9975396
• SCHEMBL20399550
• BDBM25118
• CHEBI:91395