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MITOTANE
SynDRA canonical compound SYN0017574 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP11B1 |
|---|
| Mechanism of action | Anti-neoplastic agent |
|---|
| Indication | adrenal cortical carcinoma |
|---|
| Disease area | oncology |
|---|
All known targets
- CYP11A1
- CYP11B1
- ESR1
- ADORA3
- ADRA2A
- CYP3A4
- FDX1
- HTR2B
- HTR6
- SLC6A2
- SLC6A3
- SLC6A4
Mechanisms of action (all sources)
- Anti-neoplastic agent
- CYP11A1 INHIBITOR
- Cytochrome P450 11A1 inhibitor
- CYP11B1 INHIBITOR
- Cytochrome P450 11B1 inhibitor
- antineoplastic agent
- ESR1 BINDER
Drug classes
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Cytochrome P450 3A4 Inducers
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- chloditan
- chlodithane
- lysodren
- mitotan
- opeprim
- Mitotano
- Chloditan
- Chlodithane
- Mitotan
- O,p'-ddd
- O,p'-ddd,o p'-tde
- O,p'-tde
- Opeprim
- CB-313
- NSC-38721
- Lysodren
- Opddd
- Chlodithan
- Khloditan
- Khlodithan
- Mitotanum
- Mytotan
- Bristol-Myers Squibb Brand of Mitotane
- C 3010
- CB313
- PS694_SUPELCO
- Lysodren (TN)
- Mitotano [INN-Spanish]
- Mitotanum [INN-Latin]
- Ortho,para-DDD
- Mitotane [USAN:INN:JAN]
- O,p-DDD
- O,p-Tde
- Mitotane (JAN/USP/INN)
- O,p'-DDD
- O,p'-Dichlorodiphenyldichloroethane
- O,p'-TDE
- Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-(8CI)
Reported adverse events
- Albuminuria
- Dizziness
- Dyspnoea
- Hepatitis
- Hepatotoxicity
- Hypertension
- Infection
- Leukopenia
- Maculopathy
- Muscular weakness
- Opportunistic infection
- Rash
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