← SynDRA

NAVITOCLAX

SynDRA canonical compound SYN0018460 — structure-anchored drug synonym record

All known targets

• BCL2
• BCL2L1
• BCL2L2
• CCND1

Mechanisms of action (all sources)

• BCL inhibitor
• BCL2 inhibitor
• Apoptosis regulator Bcl-2 inhibitor
• BCL2L1 INHIBITOR
• Apoptosis regulator Bcl-X inhibitor
• BCL2L2 INHIBITOR
• Apoptosis regulator Bcl-W inhibitor
• CCND1 INHIBITOR

Drug classes

• Antineoplastic Agents

ATC classes

• L01X · OTHER ANTINEOPLASTIC AGENTS

Cross-references

• PubChem CID: 24978538
• ChEMBL: CHEMBL443684
• DrugBank: DB12340
• ChEBI: 94128
• KEGG: D09935
• PDB: 1XJ
• Wikipedia: Navitoclax
• TTD: D06ETI
• LINCS BRD: BRD-K82746043

Synonyms

• A-855071.0
• ABT-263
• ABT 263
• S1001_Selleck
• ABT263, Navitoclax
• 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-({(1R)-3-morpholin-4-yl-1-[(phenylsulfanyl)methyl]propyl}amino)-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)benzamide
• ABT263
• ABT-263 (Navitoclax)
• Navitoclax (ABT-263)
• UNII-XKJ5VVK2WD
• XKJ5VVK2WD
• CHEMBL443684
• (R)-4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide
• 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
• 4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
• (R)-4-(4-((2-(4-Chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)p
• (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide
• 4-(4-{[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-En-1-Yl]methyl}piperazin-1-Yl)-N-[(4-{[(2r)-4-(Morpholin-4-Yl)-1-(Phenylsulfanyl)butan-2-Yl]amino}-3-[(Trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide
• Navitoclax [USAN]
• Navitoclax [USAN:INN]
• navitoclaxum
• C47H55ClF3N5O6S3
• 4-(4-((2-(4-CHLOROPHENYL)-5,5-DIMETHYLCYCLOHEX-1-EN-1-YL)METHYL)PIPERAZIN-1-YL)-N-((4-(((2R)-4-(MORPHOLIN-4-YL)-1-(PHENYLSULFANYL)BUTAN-2-YL)AMINO)-3-((TRIFLUOROMETHYL)SULFONYL)PHENYL)SULFONYL)BENZAMIDE
• ABT-263,Navitoclax
• NAVITOCLAX [MI]
• ABT-263 In Bulk
• Navitoclax, ABT-263
• Navitoclax; ABT-263
• NAVITOCLAX [INN]
• NAVITOCLAX [JAN]
• Navitoclax (USAN/INN)
• ABT-263 - Navitoclax
• NAVITOCLAX [WHO-DD]
• MLS006011021
• SCHEMBL522847
• GTPL8319
• DTXSID2042640
• CHEBI:94128