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CLOFARABINE
SynDRA canonical compound SYN0020292 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | RRM2 |
|---|
| Mechanism of action | Ribonucleoside reductase inhibitor |
|---|
| Indication | acute lymphoblastic leukemia (ALL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- POLA1
- RRM2
- RRM1
- POLD1
- POLE
- PDE2A
- PRPS1
- UCK1
- SLC22A8
- RRM2B
- RIR
- PRIM1
Mechanisms of action (all sources)
- Ribonucleoside reductase inhibitor
- POLA1 INHIBITOR
- DNA polymerase (alpha/delta/epsilon) inhibitor
- POLD4 INHIBITOR
- POLD3 INHIBITOR
- POLD1 INHIBITOR
- POLD2 INHIBITOR
- POLE INHIBITOR
- POLA2 INHIBITOR
- PRIM1 INHIBITOR
- PRIM2 INHIBITOR
- POLE2 INHIBITOR
Drug classes
- Nucleic Acid Synthesis Inhibitors
- Nucleoside Metabolic Inhibitor
- Antimetabolites
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Noxae
ATC classes
Cross-references
Synonyms
- ivozall
- clofarex
- clolar
- evoltra
- Clofarabina
- NSC-759857
- Clolar
- Evoltra
- Ivozall
- CAFdA
- CFB
- Clofarabinum
- Clofarex
- Clofarabine [USAN]
- Clolar (TN)
- Evoltra (TN)
- Clofarabine (USAN/INN)
- Clolar, Evoltra, Clofarabine
- Cl-F-Ara-A
- (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
- 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
- 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
- 2-Cl-2'-F-araA
- 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
- 3S211048
- C1-F-Ara-A
- CHEBI:681569
- (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
- 762RDY0Y2H
- 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-
- (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- NSC 759857
- clofarabina
- clofarabinum
- Cl-F-araA
- MFCD00871077
- (2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
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