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MIDOSTAURIN
SynDRA canonical compound SYN0020744 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | KIT |
|---|
| Mechanism of action | FLT3 inhibitor |
|---|
| Indication | acute myeloid leukemia (AML) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- FLT3
- KIT
- KDR
- PDGFRB
- PRKCA
- PRKCG
- FLT1
- PRKD3
- PDGFRA
- PRKCQ
- PRKCH
- PRKCE
Mechanisms of action (all sources)
- KIT INHIBITOR
- PKC inhibitor
- FLT3 INHIBITOR
- Tyrosine-protein kinase receptor FLT3 inhibitor
- Stem cell growth factor receptor inhibitor
- PDGFRB INHIBITOR
- Platelet-derived growth factor receptor inhibitor
- PDGFRA INHIBITOR
- PRKD3 INHIBITOR
- Protein kinase C (PKC) inhibitor
- PRKCI INHIBITOR
- PRKCA INHIBITOR
Drug classes
- Receptor Tyrosine Kinase Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Protein Kinase Inhibitors
- Kinase Inhibitor
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- CGP 41251
- PKC 412
- rydapt
- Midostaurine
- Midostaurina
- N-benzoylstaurosporine
- PKC-412
- CGP-41251
- NSC-656576
- NVP-PKC412
- Rydapt
- PKC412
- 4'-N-Benzoylstaurosporine
- Benzoylstaurosporine
- RYDAPT
- UNII-ID912S5VON
- N-Benzoylstaurosporine
- ID912S5VON
- CHEMBL608533
- CHEBI:63452
- Cgp 41 251
- N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide
- PKC-412(Midostaurin)
- Midostaurin (PKC412)
- Midostaurin (USAN/INN)
- Midostaurin [USAN:INN]
- CGP 41231
- Rydapt (TN)
- CPG 41251
- NSC 656576
- N-((9S,10R,11R,13R)-10-methoxy-9-methyl-1-oxo-2,3,10,11,12,13-hexahydro-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methylbenzamide
- Midostaurin [INN]
- Midostaurin(PKC412)
- 4-N-benzoylstaurosporine
- MIDOSTAURIN [MI]
- Staurosporine, N-Benzoyl
- MIDOSTAURIN [JAN]
- MIDOSTAURIN [USAN]
Reported adverse events
- Abdominal pain
- Activated partial thromboplastin time prolonged
- Acute febrile neutrophilic dermatosis
- Arthralgia
- Chills
- Constipation
- Cough
- Disturbance in attention
- Dizziness
- Dry skin
- Dyspepsia
- Electrocardiogram QT prolonged
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