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EPLERENONE
SynDRA canonical compound SYN0022001 — structure-anchored drug synonym record
| Clinical phase | Launched |
| Approval status | Approved · Rx/OTC |
| Primary target(s) | NR3C2 |
| Mechanism of action | Cytochrome P450 inhibitor |
| Indication | congestive heart failure | hypertension |
| Disease area | cardiology |
All known targets
- NR3C2
- AR
- CYP3A5
- NR3C1
- Nr3c2
- PGR
Mechanisms of action (all sources)
- Cytochrome P450 inhibitor
- NR3C2 ANTAGONIST
- Mineralocorticoid receptor antagonist
- NR3C2 MODULATOR
Drug classes
- Aldosterone Antagonists
- Aldosterone Antagonist
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretics
- Hormone Antagonists
- Mineralocorticoid Receptor Antagonists
- Natriuretic Agents
ATC classes
- C03D · ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Cross-references
Synonyms
- (+)-Eplerenone
- epoxymexrenone
- Eplerenona
- SC-66110
- SC-6611O
- Inspra
- Epoxymexrenone
- Selara
- CGP-30083
- Inspra (TN)
- Eplerenone (JAN/USAN/INN)
- Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
- 7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
- CHEMBL1095097
- CHEBI:31547
- 6995V82D0B
- 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester
- NCGC00159559-02
- methyl (1'R,2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate
- Eplerenone [USAN]
- Epleremone
- methyl (1'R,2S,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate
- CAS-107724-20-9
- HSDB 7522
- Eplerenone [USAN:INN:BAN]
- UNII-6995V82D0B
- Eplerenone- Bio-X
- SC 6110
- EPLERENONE [MI]
- EPLERENONE [INN]
- EPLERENONE [JAN]
- EPLERENONE [HSDB]
- EPLERENONE [VANDF]
- EPLERENONE [MART.]
- EPLERENONE [USP-RS]
- EPLERENONE [WHO-DD]
- SCHEMBL21515
- GTPL2876
Reported adverse events
- Hypertension
- Abdominal pain
- Cough
- Dizziness
- Fatigue
- Hepatic failure
- Influenza
- Proteinuria
- Albuminuria
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