← SynDRA

PONATINIB

SynDRA canonical compound SYN0022613 — structure-anchored drug synonym record

All known targets

• RET
• ABL1
• KIT
• FLT3
• FGFR1
• FGFR3
• FGFR4
• FGFR2
• BCR
• TEK
• LYN
• LCK

Mechanisms of action (all sources)

• FLT3 INHIBITOR
• PDGFR inhibitor
• Abl kinase inhibitor
• ABL1 INHIBITOR
• CDK19 INHIBITOR
• CDK8 INHIBITOR
• RIPK1 INHIBITOR
• RIPK2 INHIBITOR
• RIPK3 INHIBITOR
• RET INHIBITOR
• Bcr-Abl kinase inhibitor
• PDGFR tyrosine kinase receptor inhibitor

Drug classes

• Protein Kinase Inhibitors
• Antineoplastic Agents
• Enzyme Inhibitors
• Kinase Inhibitor
• Tyrosine Kinase Inhibitors

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 24826799
• ChEMBL: CHEMBL1171837
• DrugBank: DB08901
• ChEBI: CHEBI:78543
• KEGG: D09950
• RxNorm: 1364347
• PDB: 0LI
• Wikipedia: Ponatinib
• TTD: D0H0EQ
• LINCS BRD: BRD-K44227013

Synonyms

• iclusig
• AP24534
• ponatinib hydrochloride
• ponatinib HCl
• AP-24534
• Iclusig
• Iclusig (TN)
• 1114544-31-8 (HCl)
• 3-((imidazo(1,2-b)pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide--hydrogen chloride
• 3-(2-(Imidazo(1,2-b)pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide monohydrochloride
• 3-(2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl)benzamide hydrochloride
• 3-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide hydrochloride
• 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
• 3-(imidazo(1,2-b)pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride
• 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride
• 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide hydrochloride
• 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide--hydrogen chloride
• 4-((4-(3-((imidazo(1,2-b)pyridazin-3-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)phenyl)methyl)-1-methylpiperazin-1-ium chloride
• 4-(4-(3-(imidazo(1,2-b)pyridazin-3-ylethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)-1-methylpiperazin-1-ium chloride
• 4-{[4-{3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methylbenzamido}-2-(trifluoromethyl)phenyl]methyl}-1-methylpiperazin-1-ium chloride
• 4-{4-[3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamido]-2-(trifluoromethyl)benzyl}-1-methylpiperazin-1-ium chloride
• 943319-70-8 free base
• 96R6PU3D8J
• AC-32047
• AKOS030621539
• AMY367
• AP-24534 HCl
• AP-24534 hydrochloride
• AP24534 HCL
• AS-16772
• BCP10906
• Benzamide, 3-(2-Imidazo(1,2-B)Pyridazin-3-Ylethynyl)-4-Methyl-N-(4-((4-Methyl-1-Piperazinyl)Methyl)-3-(Trifluoromethyl)Phenyl)-, Hydrochloride (1:1)
• C29H28ClF3N6O
• CHEBI:191940
• CHEMBL2105708
• CS-0031009
• D09951
• DTXCID0072146