SEVOFLURANE

SynDRA canonical compound SYN0023133 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	ATP2C1 \| ATP5D \| CYP2E1 \| GABRA1 \| GABRA2 \| GABRA3 \| GABRA4 \| GABRA5 \| GABRA6 \| GABRB1 \| GABRB2 \| GABRB3 \| GABRD \| GABRE \| GABRG1 \| GABRG2 \| GABRG3 \| GABRP \| GABRQ \| GLRA1 \| GLRB \| GRIA1 \| KCNA1 \| KCNK10 \| KCNK18 \| KCNK2 \| KCNK3 \| KCNK9 \| MT-ND1
Mechanism of action	membrane integrity inhibitor
Indication	anesthetic
Disease area	neurology/psychiatry

All known targets

KCNK18
KCNK9
KCNK2
GLRA1
KCNK3
KCNK10
GABRE
GLRB
GABRQ
GABRP
GABRG3
GABRG2

Mechanisms of action (all sources)

GLRA1 POSITIVE MODULATOR
Glycine receptor (alpha-1/beta) positive modulator
GLRB POSITIVE MODULATOR
KCNK10 OPENER
Potassium channel subfamily K member 10 opener
KCNK18 OPENER
Potassium channel subfamily K member 18 opener
KCNK3 OPENER
Potassium channel subfamily K member 3 opener
KCNK9 OPENER
Potassium channel subfamily K member 9 opener
KCNK2 OPENER

Drug classes

Anesthetics
Anesthetics, Inhalation
Central Nervous System Agents
Central Nervous System Depressants
Hematologic Agents
Platelet Aggregation Inhibitors
General Anesthetic

ATC classes

N01A · ANESTHETICS, GENERAL

Cross-references

PubChem CID: 5206
ChEMBL: CHEMBL1200694
DrugBank: DB01236
ChEBI: CHEBI:9130
KEGG: D00547
RxNorm: 36453
PDB: A1IPI
Wikipedia: Sevoflurane
TTD: D0W6ZF

Synonyms

Reported adverse events

Agitation
Bradycardia
Bronchospasm
Cough
Dizziness
Headache
Hypertension
Hypotension
Hypothermia
Nausea
Pruritus
Tachycardia

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