BENZTROPINE

SynDRA canonical compound SYN0023464 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	CHRM1
Mechanism of action	Acetylcholine receptor antagonist
Indication	extrapyramidal symptoms (eps), parkinson's disease
Disease area	neurology/psychiatry

All known targets

CHRM1
HRH1
SLC6A3
HRH2
Slc6a3
SLC6A4
SLC6A2
SLC6A19
SIGMAR1
Pgrmc1
HTR6
HTR2C

Mechanisms of action (all sources)

Acetylcholine receptor antagonist
CHRM1 ANTAGONIST

Drug classes

Histamine Receptor Antagonists
Cholinergic Antagonists
Anticholinergic
Anti-Dyskinesia Agents
Antiparkinson Agents
Central Nervous System Agents
Cholinergic Agents
Dopamine Agents
Dopamine Uptake Inhibitors
Membrane Transport Modulators
Muscarinic Antagonists
Neurotransmitter Agents

ATC classes

N04A · ANTICHOLINERGIC AGENTS

Cross-references

PubChem CID: 1201549
ChEMBL: CHEMBL1201203
DrugBank: DB00245
ChEBI: CHEBI:3048
KEGG: D00778
PDB: CXQ
Wikipedia: Benzatropine
TTD: D0HQ6N
LINCS BRD: BRD-K68804560

Synonyms

benzatropine
cogentin
benztropine mesilate
tropine benzohydryl ether
benztropine mesylate
Benzatropine
Benzatropina
Cobrentin
NK-02
Akitan
Benzatropinum
Benztropinum
Cogentine
Cogentinol
Benzatropine [INN]
Benzatropine mesilate
Pms Benztropine
Tropine benzohydryl ether
NK 02
Apo-Benztropine
Benzatropina [INN-Spanish]
Benzatropine (INN)
Benzatropine [INN:BAN]
Benzatropinum [INN-Latin]
Cogentin (TN)
Benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether
(1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
(1r,5r)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
(3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
(3-endo)-3-[(diphenylmethyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane
(5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
3alpha-(Diphenylmethoxy)-1alphaH,5alphaH-tropane
3alpha-(diphenylmethoxy)tropane
3alpha-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
3endo-benzhydryloxytropane
8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-(9CI)

Reported adverse events

Tachycardia
Vomiting
Heat stroke
Urinary retention

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