ACAMPROSATE

SynDRA canonical compound SYN0023520 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	GABRA1 \| GABRA2 \| GABRA3 \| GABRA4 \| GABRA5 \| GABRA6 \| GABRB1 \| GABRB2 \| GABRB3 \| GABRD \| GABRE \| GABRG1 \| GABRG2 \| GABRG3 \| GABRP \| GABRQ \| GRIN1 \| GRIN2A \| GRIN2B \| GRIN2C \| GRIN2D \| GRIN3A \| GRIN3B \| GRM5
Mechanism of action	glutamate receptor antagonist
Indication	abstinence from alcohol
Disease area	neurology/psychiatry

All known targets

GABRA1
GRIN1
GRIN3B
GRIN3A
GRIN2D
GRIN2C
GRIN2B
GRIN2A
GABRG2
GABRB3
GABRD
GABRE

Mechanisms of action (all sources)

glutamate receptor antagonist
GABRA1 POSITIVE MODULATOR
GABRG2 POSITIVE MODULATOR
GABRB3 POSITIVE MODULATOR
GRIN2D ANTAGONIST
GRIN3B ANTAGONIST
GRIN1 ANTAGONIST
GRIN2A ANTAGONIST
GRIN2B ANTAGONIST
GRIN2C ANTAGONIST
GRIN3A ANTAGONIST

Drug classes

Alcohol Deterrents
Central Nervous System Agents

ATC classes

N07B · DRUGS USED IN ADDICTIVE DISORDERS

Cross-references

PubChem CID: 71158
ChEMBL: CHEMBL1201293
DrugBank: DB00659
ChEBI: CHEBI:51041
KEGG: D02780
RxNorm: 82819
Wikipedia: Acamprosate
TTD: D0GC2M
LINCS BRD: BRD-M41783010

Synonyms

Reported adverse events

Pruritus
Flatulence
Nausea
Asthenia
Depression
Dizziness
Insomnia
Pain
Dry mouth

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