← SynDRA

SAPROPTERIN

SynDRA canonical compound SYN0023616 — structure-anchored drug synonym record

All known targets

• PAH
• TH
• DBH
• NOS1
• NOS3
• TPH1

Mechanisms of action (all sources)

• Phenylalanine 4-hydroxylase stimulant
• PAH ACTIVATOR
• Phenylalanine-4-hydroxylase activator
• TH COFACTOR
• PAH MODULATOR

Drug classes

• P-Glycoprotein Inhibitors
• Breast Cancer Resistance Protein Inhibitors
• Phenylalanine Hydroxylase Activators
• Phenylalanine Hydroxylase Activator

ATC classes

• A16A · OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS

Cross-references

• PubChem CID: 135398654
• ChEMBL: CHEMBL1201774
• DrugBank: DB00360
• ChEBI: CHEBI:59560
• KEGG: D01798
• RxNorm: 753340
• PDB: BH4
• TTD: D0Q9YT
• LINCS BRD: BRD-K36859431

Synonyms

• sapropterin hydrochloride
• tetrahydrobiopterin
• sapropterin dihydrochloride
• kuvan
• sapropterin HCl
• Sapropterine
• Sapropterina
• 6r-bh4
• Dapropterin
• R-thbp
• Tetrahydrobiopterin
• 5,6,7,8-tetrahydrobiopterin
• BRN 0544742
• CHEBI:15372
• 5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone
• L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon
• (1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol
• 5,6,7,8-erythro-tetrahydrobiopterin
• 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one
• Phenoptin
• Sapropterin hydrochloride
• Biopten (TN)
• (6R)-L-erythro-tetrahydrobiopterin
• BH4
• 6R-BH4
• EGX657432I
• R-THBP
• Sapropterinum
• 6R-5,6,7,8-Tetrahydrobiopterin
• 6R-L-5,6,7,8-Tetrahydrobiopterin
• sapropterine
• (6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin
• CHEBI:59560
• RefChem:56674
• A16AX07
• Sapropterin [INN]
• Sapropterin [MI]
• Sapropterin [VANDF]

Reported adverse events

• Headache
• Hypersensitivity
• Cough
• Nasal congestion
• Vomiting