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FEDRATINIB

SynDRA canonical compound SYN0024886 — structure-anchored drug synonym record

All known targets

• JAK2
• FLT3
• TYK2
• JAK3
• JAK1
• BRD4
• RET
• PHKG1
• PDGFRB
• PDGFRA
• PAK6
• PAK5

Mechanisms of action (all sources)

• JAK inhibitor
• FLT3 INHIBITOR
• Tyrosine-protein kinase receptor FLT3 inhibitor
• JAK2 INHIBITOR
• Tyrosine-protein kinase JAK2 inhibitor
• BET bromodomain inhibitor
• JAK1 INHIBITOR
• JAK3 INHIBITOR
• TYK2 INHIBITOR

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 16722836
• ChEMBL: CHEMBL1287853
• DrugBank: DB12500
• ChEBI: 91408
• KEGG: D10630
• RxNorm: 2197490
• PDB: 2TA
• Wikipedia: Fedratinib
• TTD: D0G8BM
• LINCS BRD: BRD-K12502280

Synonyms

• fedratinib hydrochloride
• SAR302503
• SAR-302503
• TG101348
• TG-101348
• FEDR
• inrebic
• TG.101348
• TG 101348
• SAR 302503
• N-(tert-butyl)-3-((5-methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide
• Inrebic
• Fedratinib (SAR302503, TG101348)
• N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide
• TG101348 (SAR302503)
• CHEMBL1287853
• 6L1XP550I6
• 936091-26-8 (free base)
• N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
• Benzenesulfonamide, N-(1,1-dimethylethyl)-3-((5-methyl-2-((4-(2-(1-pyrrolidinyl)ethoxy)phenyl)amino)-4-pyrimidinyl)amino)-
• N-Tert-butyl-3-(5-methyl-2-(4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino)-pyrimidin-4-ylamino)-benzenesulfonamide
• N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide
• Fedratinib [USAN]
• Fedratinib [USAN:INN]
• UNII-6L1XP550I6
• C27H36N6O3S
• 2TA
• FEDRATINIB [MI]
• FEDRATINIB [INN]
• Fedratinib (USAN/INN)
• TG101348(Fedratinib)
• FEDRATINIB [WHO-DD]
• Fedratinib (TG101348)
• MLS006011155
• N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
• SCHEMBL263741
• GTPL5716
• CHEBI:91408

Reported adverse events

• Wernicke's encephalopathy
• Amylase increased
• Aspartate aminotransferase increased
• Blood creatinine increased
• Bone pain
• Dizziness
• Dysuria
• Encephalopathy
• Fatigue
• Headache
• Lipase increased
• Muscle spasms