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SELUMETINIB

SynDRA canonical compound SYN0025683 — structure-anchored drug synonym record

All known targets

• MAP2K1
• MAP2K2
• AAK1
• BMP2K
• CSNK2A2
• EGFR
• SMC1A
• SMC2

Mechanisms of action (all sources)

• MEK inhibitor
• MAP2K1 INHIBITOR
• Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
• MAP2K2 INHIBITOR
• Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
• MAP2K1 NEGATIVE ALLOSTERIC MODULATOR

Drug classes

• Kinase Inhibitor
• Mitogen-Activated Protein Kinase Kinase 1 Inhibitors
• Mitogen-Activated Protein Kinase Kinase 2 Inhibitors

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 10127622
• ChEMBL: CHEMBL1614701
• DrugBank: DB11689
• ChEBI: CHEBI:90227
• KEGG: D10024
• RxNorm: 2289380
• PDB: 3EW
• Wikipedia: Selumetinib
• TTD: D0T5DP
• LINCS BRD: BRD-K57080016

Synonyms

• selumetinib sulfate
• koselugo
• AZD6244
• ARRY-142886
• AZD-6244
• ARRAY142886
• ARRY-886
• AZD-6244 HYD-SULFATE
• AZD-6244 HYDROGEN SULFATE
• AZD6244 (SELUMETINIB)
• SELUMETINIB (AZD6244)
• Selumetinib sulfate
• AZD 6244
• ARRY142886
• 6UH91I579U
• AZD6244 (Selumetinib)
• AZD6244(Selumetinib)
• CHEBI:90227
• CHEMBL1614701
• MEK inhibitors
• Selumetinib (AZD6244)
• UNII-6UH91I579U
• ARRY 142886
• 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE
• 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
• Koselugo
• 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-N-(2-hydroxyethoxy)-1-Methyl-1H-benzo[d]iMidazole-6-carboxaMide
• NSC741078
• NCGC00189073-01
• NCGC00189073-02
• 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
• 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
• 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide
• 6-[(4-bromo-2-chlorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
• AZD 6244;5-((4-Bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide;6-(4-bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide
• CAS-606143-52-6
• Selumetinib [USAN:INN]
• selumetinibum

Reported adverse events

• Dermatitis
• Dry skin
• Nausea
• Paronychia
• Pyrexia
• Rash
• Stomatitis
• Vomiting
• Abdominal pain
• Constipation
• Epistaxis
• Fatigue