← SynDRA

TRAMETINIB

SynDRA canonical compound SYN0030073 — structure-anchored drug synonym record

All known targets

• MAP2K1
• MAP2K2
• ABCB1
• CYP2C8
• CYP3A4

Mechanisms of action (all sources)

• MEK inhibitor
• MAP2K2 INHIBITOR
• Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
• MAP2K1 INHIBITOR
• Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
• Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor

Drug classes

• Protein Kinase Inhibitors
• Antineoplastic Agents
• Enzyme Inhibitors
• Kinase Inhibitor

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 11707110
• ChEMBL: CHEMBL2103875
• DrugBank: DB08911
• ChEBI: CHEBI:75998
• KEGG: D10175
• RxNorm: 1425099
• PDB: QOM
• Wikipedia: Trametinib
• TTD: D04XVN
• LINCS BRD: BRD-K12343256

Synonyms

• GSK1120212B
• trametinib dimethyl sulfoxide
• GSK1120212
• mekinist
• TMT212
• CPD 8B
• GSK-1120212
• JTP-74057
• Mekinist
• TMT-212
• TRAMETINIB (GSK1120212)
• Trametinib dimethyl sulfoxide
• Trametinib (GSK1120212)
• Trametinib (GSK1120212JTP 74057)
• Trametinib (MEK inhibitor)
• 33E86K87QN
• A1-01871
• AK174783
• CHEBI:75998
• UNII-33E86K87QN
• GSK 1120212
• N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
• GSK212
• Trametinib [USAN]
• N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
• Trametinib (USAN)
• N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide
• Acetamide, N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-3,4,6,7-tetrahydro-6,8- dimethyl-2,4,7-trioxopyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)-
• N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
• Trametinib [USAN:INN]
• trametinibum
• JTP74057
• N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide
• N-(3-{3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl}phenyl)acetamide
• QOM
• TRAMETINIB [MI]
• TRAMETINIB [INN]
• TRAMETINIB [VANDF]

Reported adverse events

• Abdominal pain
• Acne
• Alopecia
• Anxiety
• Arthralgia
• Atrioventricular block
• Atrioventricular block complete
• Bradycardia
• Cardiomyopathy
• Chills
• Colitis
• Constipation