← SynDRA

RIOCIGUAT

SynDRA canonical compound SYN0033278 — structure-anchored drug synonym record

All known targets

• GUCY1B3
• GUCY1A1
• GUCY1A1|GUCY1B1
• GUCY1A2
• GUCY1A2|GUCY1B1
• GUCY1A3
• GUCY1B1
• GUCY1B2
• GUCY2D
• PDE7B

Mechanisms of action (all sources)

• Guanylate cyclase stimulant
• GUCY1A1|GUCY1B1 ACTIVATOR
• GUCY1A2|GUCY1B1 ACTIVATOR
• Modulator
• GUCY1B3 POSITIVE ALLOSTERIC MODULATOR

Drug classes

• Enzyme Activators
• Guanylate Cyclase Stimulators
• Soluble Guanylate Cyclase Stimulator

ATC classes

• C02K · OTHER ANTIHYPERTENSIVES

Cross-references

• PubChem CID: 11304743
• ChEMBL: CHEMBL2107834
• DrugBank: DB08931
• ChEBI: CHEBI:76018
• KEGG: D09572
• RxNorm: 1439816
• PDB: GZO
• Wikipedia: Riociguat
• TTD: D04UKC
• LINCS BRD: BRD-K84783599

Synonyms

• adempas
• BAY 63-2521
• Bay 63-2521
• Adempas
• Riociguat (BAY 63-2521)
• riociguatum
• UNII-RU3FE2Y4XI
• RU3FE2Y4XI
• CHEBI:76018
• Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate
• Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
• N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
• BAY-63-2521
• methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
• methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-N-methylcarbamate
• Riociguat [INN]
• methyl ~{N}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{N}-methyl-carbamate
• Methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl(methyl)carbamate
• Riociguate
• Riociguat [USAN:INN:JAN]
• Riocguat-d3
• Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl(methyl)carbamate
• Adempas (TN)
• BAY-632521
• RIOCIGUAT [JAN]
• RIOCIGUAT [MI]
• RIOCIGUAT [USAN]
• RIOCIGUAT [VANDF]
• RIOCIGUAT [USP-RS]
• RIOCIGUAT [WHO-DD]
• Bay 63-2521,Riociguat
• Riociguat (JAN/USAN/INN)
• SCHEMBL245457
• GTPL5257
• RIOCIGUAT [ORANGE BOOK]
• CHEMBL2107834
• RIOCIGUAT [EP MONOGRAPH]
• AMY4218

Reported adverse events

• Constipation
• Dizziness
• Dyspepsia
• Gastritis
• Headache
• Hypotension
• Nausea
• Vomiting