← SynDRA

ALPELISIB

SynDRA canonical compound SYN0037409 — structure-anchored drug synonym record

All known targets

• PIK3CA
• PIK3CB
• PIK3CD
• PIK3CG
• GAK
• MTOR
• PRKACG
• Pik3cb

Mechanisms of action (all sources)

• PI3K inhibitor
• PIK3CA INHIBITOR
• PI3-kinase p110-alpha subunit inhibitor

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 56649450
• ChEMBL: CHEMBL2396661
• DrugBank: DB12015
• ChEBI: 93752
• KEGG: D11011
• RxNorm: 2169285
• PDB: 1LT
• Wikipedia: Alpelisib
• TTD: D0W7HE
• LINCS BRD: BRD-K54997624

Synonyms

• piqray
• BYL-719
• NVP-BYL-719
• vijoice
• VIJOICE
• ALPELISIB (BYL719)
• BYL719
• NVP-BYL719
• Piqray
• BYL 719
• UNII-08W5N2C97Q
• Alpelisib (BYL719)
• (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide
• (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
• CHEMBL2396661
• 08W5N2C97Q
• AK146107
• C19H22F3N5O2S
• (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide
• Vijoice
• (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
• (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-(4-methyl-5-(2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl)thiazol-2-yl)amide
• 1,2-Pyrrolidinedicarboxamide, N1-(4-methyl-5-(2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl)-2-thiazolyl)-, (2S)-
• 1,2-PYRROLIDINEDICARBOXAMIDE, N1-[4-METHYL-5-[2-(2,2,2-TRIFLUORO-1,1-DIMETHYLETHYL)-4-PYRIDINYL]-2-THIAZOLYL]-, (2S)-
• Alpelisib [INN]
• (2s)-N~1~-{4-Methyl-5-[2-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)pyridin-4-Yl]-1,3-Thiazol-2-Yl}pyrrolidine-1,2-Dicarboxamide
• (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide.
• 4jps
• 1LT
• Alpelisib [USAN]
• Piqray (TN)
• ALPELISIB [JAN]
• ALPELISIB [MI]
• Alpelisib [USAN:INN]
• ALPELISIB [WHO-DD]
• Alpelisib (JAN/USAN/INN)
• GTPL7955
• SCHEMBL1911869

Reported adverse events

• Abdominal pain
• Alanine aminotransferase
• Alopecia
• Angioedema
• Colitis
• Dry skin
• Dysgeusia
• Dyspepsia
• Fatigue
• Headache
• Hypersensitivity
• Lipase increased