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DEFACTINIB

SynDRA canonical compound SYN0037861 — structure-anchored drug synonym record

All known targets

• PTK2
• LATS1
• PTK2B

Mechanisms of action (all sources)

• FAK inhibitor
• PTK2 INHIBITOR
• Focal adhesion kinase 1 inhibitor
• PTK2B INHIBITOR
• Protein tyrosine kinase 2 beta inhibitor
• LATS1 INHIBITOR

Cross-references

• PubChem CID: 25117126
• ChEMBL: CHEMBL3137331
• DrugBank: DB12282
• KEGG: D10618
• RxNorm: 2714502
• PDB: 7KD
• Wikipedia: Defactinib
• TTD: D0Y1UO
• LINCS BRD: BRD-K43578482

Synonyms

• VS-6063
• DEFACITINIB
• DEFACTINIB (VS-6063)
• Defactinib hydrochloride
• PF-04554878
• PF 04554878
• VS 6063
• Defactinib (VS-6063, PF-04554878)
• N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide
• N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
• 53O87HA2QU
• Benzamide, N-methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)-2-pyrazinyl)methyl)amino)-5-(trifluoromethyl)-2-pyrimidinyl)amino)-
• VS6063
• N-Methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide
• N-methyl-4-((4-(((3-methyl(methylsulfonyl)aminopyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide
• Defactinib [USAN:INN]
• UNII-53O87HA2QU
• Defactinib [USAN]
• DEFACTINIB [INN]
• Defactinib (USAN/INN)
• DEFACTINIB [WHO-DD]
• GTPL7910
• SCHEMBL1627234
• CHEMBL3137331
• BDBM418817
• DTXSID901025937
• HMS3740O13
• AMY42170
• BCP11299
• EX-A1037
• EX-A1049
• MFCD25977806
• NSC778364
• NSC781450
• NSC782549
• NSC800089
• s7654
• US10450297, Example 317