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BINIMETINIB

SynDRA canonical compound SYN0037963 — structure-anchored drug synonym record

All known targets

• MAP2K1
• MAP2K2
• IL1R2
• IL6R
• NQO2
• TNFRSF1A

Mechanisms of action (all sources)

• MAP2K1 INHIBITOR
• Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
• MAP2K2 INHIBITOR
• Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
• MAP2K1 NEGATIVE ALLOSTERIC MODULATOR
• MAP2K2 NEGATIVE ALLOSTERIC MODULATOR
• MEK inhibitor

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 10288191
• ChEMBL: CHEMBL3187723
• DrugBank: DB11967
• ChEBI: CHEBI:145371
• KEGG: D10604
• RxNorm: 2049122
• PDB: QO7
• Wikipedia: Binimetinib
• TTD: D0C4LF
• LINCS BRD: BRD-K82244583

Synonyms

• mektovi
• MEK162
• ARRY-162
• ARRY-438162
• MEK-162
• NVP-MEK162
• Mektovi
• ARRY 162
• MEK 162
• ARRY 438162
• 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
• UNII-181R97MR71
• Binimetinib (MEK162, ARRY-162, ARRY-438162)
• 181R97MR71
• MEK162 (ARRY-162, ARRY-438162)
• 6-(4-bromo-2-fluorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide
• Binimetinib [USAN:INN]
• MEK162(Binimetinib)
• Binimetinib (JAN/USAN)
• NVP-ME
• Binimetinib (MEK-162)
• MFCD22124525
• 6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
• 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
• 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aa,5a,6aa)-octahydro- 2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-
• 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide.
• 5-(4-Bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
• 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide
• 6-[(4-bromo-2-fluorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
• binimetinibum
• Mektovi (TN)
• ARRY-162; ARRY-438162; MEK 162; ARRY 162; ARRY 438162
• Binimetinib; Mek162
• BINIMETINIB [MI]
• Binimetinib (MEK162)
• BINIMETINIB [INN]
• BINIMETINIB [JAN]
• BINIMETINIB [USAN]

Reported adverse events

• Abdominal pain
• Alopecia
• Colitis
• Constipation
• Dizziness
• Dry skin
• Dysgeusia
• Erythema
• Fatigue
• Headache
• Hyperkeratosis
• Hypertension