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CAPMATINIB

SynDRA canonical compound SYN0037968 — structure-anchored drug synonym record

All known targets

• MET
• CDKL5

Mechanisms of action (all sources)

• MET INHIBITOR
• Hepatocyte growth factor receptor inhibitor
• MET MODULATOR

Drug classes

• Kinase Inhibitor
• Cytochrome P450 1A2 Inhibitors
• P-Glycoprotein Inhibitors
• Breast Cancer Resistance Protein Inhibitors
• Multidrug and Toxin Extrusion Transporter 1 Inhibitors
• Mesenchymal Epithelial Transition Inhibitors
• Multidrug and Toxin Extrusion Transporter 2 K Inhibitors

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 25145656
• ChEMBL: CHEMBL3188267
• DrugBank: DB11791
• ChEBI: 231693
• KEGG: D10696
• RxNorm: 2362165
• Wikipedia: Capmatinib
• TTD: D07OJZ

Synonyms

• capmatinib hydrochloride
• capmatinib hydrochloride hydrate
• tabrecta
• NVP-INC280-NX
• INC280
• INCB-028060
• vcapmatinib dihydrochloride monohydrate
• INCB-28060
• CAPMATINIB (INCB28060)
• INC-280
• INCB-28060 FREE BASE
• INCB-28060A-1419
• INCB28060
• NVP-INC280
• NYP-INC280-NX
• UNII-TY34L4F9OZ
• 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
• INC28060
• INCB 28060
• INCB28060(Capmatinib)
• TY34L4F9OZ
• Capmatinib (INCB28060)
• 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide
• BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-
• C23H17FN6O
• INC.280
• 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2- yl)benzamide
• Tabrecta
• Capmatinib [USAN]
• 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
• Capmatinib(INCB28060)
• 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide
• 2-fluoro-N-methyl-4-{7-[(quinolin-6-yl)methyl]imidazo[1,2-b][1,2,4]triazin-2-yl}benzamide
• Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-;Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-
• Capmatinib [INN]
• benzamide hcl
• BENZAMIDE, 2-FLUORO-N-METHYL-4-(7-(6-QUINOLINYLMETHYL)IMIDAZO(1,2-B)(1,2,4)TRIAZIN-2-YL)-
• CAPMATINIB [MI]

Reported adverse events

• Constipation
• Cough
• Fatigue
• Hypersensitivity
• Nausea
• Pyrexia
• Rash
• Vomiting
• Weight decreased
• Decreased appetite
• Dizziness
• Hepatotoxicity