← SynDRA

ABEMACICLIB

SynDRA canonical compound SYN0038040 — structure-anchored drug synonym record

All known targets

• CDK4
• CDK6
• ICK
• IRAK1
• KCNH2
• MAP4K4
• MAPK8
• PIM1
• PRKCA
• AAK1
• GSK3A
• PRKCB

Mechanisms of action (all sources)

• CDK4/6 inhibitor
• Cyclin-dependent kinase 4 inhibitor
• Cyclin-dependent kinase 6 inhibitor
• cyclin-dependent kinase inhibitor
• CDK4 MODULATOR
• CDK6 MODULATOR

Drug classes

• Kinase Inhibitors
• Kinase Inhibitor

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 46220502
• ChEMBL: CHEMBL3301610
• DrugBank: DB12001
• ChEBI: 233362
• KEGG: D10688
• RxNorm: 1946825
• PDB: 6ZV
• Wikipedia: Abemaciclib
• TTD: D05SBO
• LINCS BRD: BRD-K33622447

Synonyms

• LY2835219
• verzenio
• LY-2835219
• ABEMACICLIB (LY2835219)
• CDK4/6 DUAL INHIBITOR
• LY-28352192-PYRIMIDINAMINE
• LY2835219 FREE BASE
• N-[5-[(4-ETHYL-1-PIPERAZINYL)METHYL]-2-PYRIDINYL]-5-FLUORO-4-[4-FLUORO-2-METHYL-1-(1-METHYLETHYL)-1H-BENZIMIDAZOL-6-YL]-
• Verzenio
• Verzenios
• UNII-60UAB198HK
• LY2835219 (free base);
• LY2835219 free base
• LY 2835219
• N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
• N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine
• Abemaciclib (ly2835219)
• 60UAB198HK
• HY-16297A
• LY2835219 free base (Abemaciclib)
• CS-1230
• 2-Pyrimidinamine, N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)
• N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-1,3-benzodiazol-5-yl)pyrimidin-2-amine
• N-{5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-amine
• LY2835219 (free base)
• Abemaciclib [USAN:INN]
• rimidin-2-amine
• Verzenio (TN)
• 6ZV
• N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine
• CDK4/6 dual inhibitor
• LY2835210
• ABEMACICLIB [MI]
• ABEMACICLIB [INN]
• ABEMACICLIB [JAN]
• Abemaciclib (JAN/USAN)
• ABEMACICLIB [USAN]
• ABEMACICLIB [WHO-DD]

Reported adverse events

• Alanine aminotransferase increased
• Alopecia
• Aspartate aminotransferase increased
• Dizziness
• Dysgeusia
• Dyspepsia
• Fatigue
• Headache
• Infection
• Lacrimation increased
• Nail disorder
• Nausea