← SynDRA

OSIMERTINIB

SynDRA canonical compound SYN0038115 — structure-anchored drug synonym record

All known targets

• EGFR
• ALK
• BTK
• CARS
• CTSC
• ERBB2
• ERBB3
• INSR
• KCNH2
• KDM1A
• NQO2
• PIP4K2C

Mechanisms of action (all sources)

• EGFR INHIBITOR
• Epidermal growth factor receptor erbB1 inhibitor

Drug classes

• Antineoplastic Agents
• Enzyme Inhibitors
• Protein Kinase Inhibitors
• Kinase Inhibitors
• Kinase Inhibitor
• Cytochrome P450 3A4 Inducers
• Breast Cancer Resistance Protein Inhibitors
• Cytochrome P450 3A Inhibitors
• Cytochrome P450 1A2 Inducers
• Tyrosine Kinase Inhibitors

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 71496458
• ChEMBL: CHEMBL3353410
• DrugBank: DB09330
• ChEBI: CHEBI:90943
• KEGG: D10766
• RxNorm: 1721560
• PDB: YY3
• Wikipedia: Osimertinib
• TTD: D0O8GK
• LINCS BRD: BRD-K42805893

Synonyms

• tagrisso
• AZD9291
• AZD 9291
• osimertinib mesylate
• osimertinib mesilate
• AZD9291 mesylate
• mereletinib
• AZD-9291
• Mereletinib
• AZD-9291 FREE BASE
• Tagrisso
• Osimertinib [USAN]
• UNII-3C06JJ0Z2O
• N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
• N-(2-{[2-(Dimethylamino)ethyl](Methyl)amino}-4-Methoxy-5-{[4-(1-Methyl-1h-Indol-3-Yl)pyrimidin-2-Yl]amino}phenyl)prop-2-Enamide
• 3C06JJ0Z2O
• MereletinibAZD-9291,Osimertinib
• N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
• 2-Propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-
• N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
• N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
• Mereletinib [INN]
• osimertinibum
• N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)acrylamide
• OSIMERTINIB [MI]
• OSIMERTINIB [INN]
• Osimertinib (AZD9291)
• Osimertinib; AZD-9291
• mereletinib (obsolete INN)
• OSIMERTINIB [WHO-DD]
• GTPL7719
• CHEMBL3353410
• SCHEMBL14660911
• CHEBI:90943
• AMY9161
• EX-A314
• DTXSID501025961
• HMS3653E10

Reported adverse events

• Blood creatinine increased
• Dry skin
• Erythema multiforme
• Keratitis
• Leukopenia
• Lymphopenia
• Neutropenia
• Pneumonitis
• Pruritus
• Rash
• Stomatitis
• Thrombocytopenia