← SynDRA

RIBOCICLIB

SynDRA canonical compound SYN0038225 — structure-anchored drug synonym record

All known targets

• CDK4
• CDK6
• CAMK2D
• CAMK2G
• CDK16
• CDK2
• CDK9
• FECH
• GAK
• JAK3
• MAP3K1
• PRKD2

Mechanisms of action (all sources)

• CDK4/6 inhibitor
• Cyclin-dependent kinase 4 inhibitor
• Cyclin-dependent kinase 6 inhibitor
• cyclin-dependent kinase inhibitor
• CDK4 MODULATOR
• CDK6 MODULATOR

Drug classes

• Kinase Inhibitors
• Kinase Inhibitor
• Cytochrome P450 3A Inhibitors

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 44631912
• ChEMBL: CHEMBL3545110
• DrugBank: DB11730
• ChEBI: 230905
• KEGG: D10883
• RxNorm: 1873916
• PDB: 6ZZ
• Wikipedia: Ribociclib
• TTD: D01HVT

Synonyms

• ribociclib succinate
• LEE011
• LEE 011
• kisqali
• LEE011-BBA
• LEE011A
• LEE-011
• LEE-011A
• NVP-LEE011
• Ribociclib Succinate
• LEE011 succinate
• LEE011 (succinate)
• UNII-BG7HLX2919
• Ribociclib succinate [USAN]
• BG7HLX2919
• Kisqali (TN)
• Ribociclib succinate (USAN)
• LEE-011 succinate
• SCHEMBL2684999
• EX-A1586
• HY-15777B
• 1374639-75-4 (succinate)
• AKOS030526460
• CS-2277
• ACN-040739
• Kisqali
• Ribociclib(LEE011)
• UNII-TK8ERE8P56
• 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
• TK8ERE8P56
• Ribociclib (LEE011)
• AK174906
• 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
• 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo [2,3-d]pyrimidine-6-carboxylic acid dimethylamide
• Ribociclib [USAN:INN]
• Tube013
• 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
• 7-Cyclopentyl-N,N-dimethyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Reported adverse events

• Infection
• Abdominal pain
• Alopecia
• Cough
• Fatigue
• Headache
• Nausea
• Neutropenia
• Rash
• Stomatitis
• Vomiting
• Back pain