← SynDRA

LAROTRECTINIB

SynDRA canonical compound SYN0038615 — structure-anchored drug synonym record

All known targets

• NTRK1
• NTRK2
• NTRK3
• TNK2

Mechanisms of action (all sources)

• NTRK1 INHIBITOR
• Neurotrophic tyrosine kinase receptor inhibitor
• NTRK2 INHIBITOR
• NTRK3 INHIBITOR
• alk tyrosine kinase receptor inhibitor
• tropomyosin receptor kinase inhibitor

Drug classes

• Kinase Inhibitor
• Tropomyosin Receptor Kinases Inhibitors

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 46188928
• ChEMBL: CHEMBL3889654
• DrugBank: DB14723
• KEGG: D11137
• RxNorm: 2105628
• Wikipedia: Larotrectinib
• TTD: D07TOK

Synonyms

• vitrakvi
• LOXO-101
• ARRY-470
• larotrectinib sulfate
• BAY-2757556
• BAY2757556
• LOXO-101 (ARRY-470)
• LOXO-101LOXO 101LOXO101A-9048
• Vitrakvi
• UNII-PF9462I9HX
• PF9462I9HX
• Larotrectinib [USAN:INN]
• GTPL8909
• SCHEMBL2241012
• NYNZQNWKBKUAII-KBXCAEBGSA-N
• BDBM136597
• ZINC118399834
• AKOS027338709
• example 14 [US8865698 B2]
• CS-5722
• HY-12866
• AS-35231
• J3.628.138C
• US8865698, 14
• ARRY470
• ARRY 470
• LOXO 101
• LOXO101
• larotrectinibum
• RefChem:57159
• L01XE53
• DTXCID001493220
• LarotrectinibFor
• MFCD28902192
• Larotrectinib (LOXO-101 free base)
• C21H22F2N6O2
• Larotrectinib [INN]
• Larotrectinib (Standard)

Reported adverse events

• Constipation
• Dizziness
• Fatigue
• Hepatotoxicity
• Nausea
• Neutropenia
• Vomiting
• Abdominal pain
• Cough
• Headache
• Leukopenia
• Muscular weakness